The XO Directory

Isabelle Dinoire is the recipient of the world's first ever facial transplant. According to her doctor, she can now smile a little. Her case shows that the controversial surgery can work—but it also highlighted the risks involved. Since the transplant, she dealt with complications such as two tissue-rejection episodes, two kidney failures, anemia and high blood pressure.

"Everyone in the world said this should not be done because the world was not ready and the risks were too high," said one plastic surgeon. Dinoire is said to be happy, and unafraid to walk the street. "She now has a human face," said one of her doctors. "If she wanted to kiss someone, she could."

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